This study evaluated the effect of intra-hippocampal injection of JQ1 on cognitive deficiency
and protein level of c-Fos and brain-derived neurotrophic factor (BDNF) in the hippocampus …

Abstract Background Histone deacetylases (HDACs) target various genes responsible for
cognitive functions. However, chromatin readers, particularly bromodomain-containing …

Communication between astrocytes and neurons has a profound effect on the
pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase …

Objective: To investigate the mechanism of Moxibustion pretreatment in prevention and cure
of Alzheimer's disease (AD). Methods: Rats were randomly divided into normal, sham …

Our previous studies demonstrate that a non-cholinesterase inhibitor (AChEI) compound
catalpol, purified from a traditional Chinese medicinal herb Rehmannia glutinosa, could …

Abstract Cu‑zhi‑2‑hao‑fang (CZ2HF), a traditional Chinese medicine, has been used
clinically for the treatment of amnesia. However, whether CZ2HF is capable of alleviating …

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
extracellular amyloid plaques and intracellular neurofibrillary tangles. It is the most common …

Objective To explore the effects of proBDNF on cell proliferation and differentiation in
hippocampal dentate gyrus in Alzheimer'disease (AD) rat model. Methods The AD rat model …

The aim of this study was to investigate the effects of histone deacetyltase (HDAC) 6 on the
functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction …

Although amyloid β protein (Aβ) has been recognized as one of the main pathological
characteristics in the brain of Alzheimer's disease (AD), the effective strategies against Aβ …