Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D
mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas …

Mutations affecting enhancer chromatin regulators CREBBP and KMT2D are highly co-
occurrent in germinal center (GC)-derived lymphomas and other tumors, even though …

Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss
of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice …

The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …

Heterozygous inactivating mutations of the KMT2D methyltransferase and the CREBBP
acetyltransferase are among the most common genetic alterations in B cell lymphoma and …

Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …

Follicular lymphoma (FL) is a prototypical example of germinal center (GC) derived B-cell
lymphoma. Using a mouse model recapitulating the sporadic occurrence of the FL hallmark …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

Germinal center (GC) B cells feature repression of many gene enhancers to establish their
characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs …

Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which
contributes to drug resistance, necessitating development of novel therapeutic approaches …