Objectives Socioeconomic status (SES) is a powerful determinant of health, but the
underlying biological mechanisms are poorly understood. This study investigates whether …

Aim: To examine variation in child DNA methylation to assess its potential as a pathway for
effects of childhood social adversity on health across the life course. Materials & methods: In …

Prenatal development and early childhood are critical periods for establishing the tissue-
specific epigenome, and may have a profound impact on health and disease in later life …

Objectives Differences in DNA methylation have been associated with early life adversity,
suggesting that alterations in methylation function as one pathway through which adverse …

Background Disadvantaged socio-economic position (SEP) in childhood is associated with
increased adult mortality and morbidity. We aimed to establish whether childhood SEP was …

Epigenetics is emerging as an attractive mechanism to explain the persistent genomic
embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into …

Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …

There is extensive variation in DNA methylation between individuals and ethnic groups.
These differences arise from a combination of genetic and non-genetic influences and …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

Background Socioeconomic position (SEP) is a major determinant of health across the life
course. Yet, little is known about the biological mechanisms explaining this relationship. One …