The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury

N Wada, T Shimizu, N Shimizu… - Neurourology and …, 2018 - Wiley Online Library
Aims To investigate the role of nerve growth factor (NGF) in lower urinary tract dysfunction in
mice with spinal cord injury (SCI). Methods Using 4‐week SCI mice, single‐filling cystometry …

Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats

S Seki, K Sasaki, Y Igawa, O Nishizawa… - The Journal of …, 2004 - auajournals.org
Purpose: We investigated the effects of intrathecal application of nerve growth factor (NGF)
antibodies (NGF-Abs) and desensitization of C-fiber afferent pathways by capsaicin …

Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury

N Shimizu, N Wada, T Shimizu, T Suzuki, E Takaoka… - Neuroscience …, 2018 - Elsevier
Nerve growth factor (NGF) is reportedly involved in the changes in C-fiber bladder afferent
pathways that induce detrusor overactivity (DO) following spinal cord injury (SCI). This study …

Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats

N Yoshimura, NE Bennett, Y Hayashi… - Journal of …, 2006 - Soc Neuroscience
Nerve growth factor (NGF) has been proposed as an important mediator inducing bladder
overactivity under pathological conditions such as spinal cord injury, bladder outlet …

Therapeutic effects of inhibition of brain-derived neurotrophic factor on voiding dysfunction in mice with spinal cord injury

N Wada, T Shimizu, N Shimizu… - American Journal …, 2019 - journals.physiology.org
We investigated the involvement of brain-derived neurotrophic factor (BDNF) in bladder and
urethral dysfunction using spinal cord-injured mice. We evaluated bladder and urethral …

Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cord

P Zvara, MA Vizzard - BMC physiology, 2007 - Springer
Background Exogenous NGF or saline was delivered to the detrusor smooth muscle of
female rats for a two-week period using osmotic mini-pumps. We then determined:(1) …

The early, long‐term inhibition of brain‐derived neurotrophic factor improves voiding, and storage dysfunctions in mice with spinal cord injury

N Wada, N Yoshimura, M Kurobe… - Neurourology and …, 2020 - Wiley Online Library
Aims We examined the time course of urodynamic changes and the effect of the short or
long‐term inhibition of brain‐derived neurotrophic factor (BDNF) from the early phase after …

Nerve growth factor‐dependent hyperexcitability of capsaicin‐sensitive bladder afferent neurones in mice with spinal cord injury

T Shimizu, T Majima, T Suzuki, N Shimizu… - Experimental …, 2018 - Wiley Online Library
New Findings What is the central question of this study? Nerve growth factor (NGF) is
reportedly a mediator inducing urinary bladder dysfunction. Is NGF directly involved in …

Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy

WD Steers, DJ Creedon, JB Tuttle - The Journal of urology, 1996 - auajournals.org
Purpose: The goal of this investigation was to examine the effect of immunity to nerve growth
factor (NGF) on alterations in sensory nerves from the urinary bladder in the dorsal root …

Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord …

K Kadekawa, T Yoshizawa, N Wada, T Shimizu… - Experimental …, 2017 - Elsevier
Purpose To examine (1) whether spinal cord injury (SCI) time-dependently increases the
severity of autonomic dysreflexia (AD) and expression levels of bladder nerve growth factor …