Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

Epilepsy is a common and heterogeneous neurological disorder arising from biochemical
and molecular events that are incompletely understood. To effectively manage epilepsies, it …

Epilepsy is a neurological disorder characterized by spontaneous, recurrent and paroxysmal
cerebral discharge, clinically leading to persistent alterations in function and morphology of …

Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

Oxidative stress resulting from excessive free-radical release is likely implicated in the
initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing …

Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders
and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy …

Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Background: Neuronal hyperexcitability and excessive production of free radicals have been
implicated in the pathogenesis of a considerable range of neurological disorders, including …

Clinical and experimental data hints that prolonged and repeated epileptic seizures can
lead to molecular, biochemical, metabolic, and structural changes in the brain, a continuous …