Methods for the chemical synthesis of RNA have been available for almost half century, and
presently, RNA could be chemically synthesized by automated synthesizers, using protected …

RNA can be chemically synthesized by automated DNA/RNA synthesizers, using protected
ribonucleosides activated as phosphoramidites. The efficiency of the synthesis depends …

RNA plays a myriad of roles in the body including the coding, decoding, regulation, and
expression of genes. RNA oligonucleotides have garnered significant interest as …

Our group is working on the development of reliable access to biologically relevant, long,
and modified RNA sequences. Here, we briefly present the chemical synthesis of such …

The biological potential of RNA along with the variety of possible applications has led to an
increased demand for large-scale production of RNA molecules. Recent developments in …

In recent years, RNA has emerged as a medium with a broad spectrum of therapeutic
potential, however, for years, a group of short RNA fragments was studied and considered …

Recent studies on the chemical synthesis of RNA and related derivatives are reviewed. In
particular, a variety of new 2′-hydroxyl protecting groups that are developed during the …

The chemical synthesis of modified oligoribonucleotides represents a powerful approach to
study the structure, stability, and biological activity of RNAs. Selected RNA modifications …

Both natural and unnatural modifications in RNA are of interest to biologists and chemists.
More than 100 different analogues of the four standard RNA nucleosides have been …

Conspectus Efforts to chemically modify nucleic acids got underway merely a decade after
the discovery of the DNA double helix and initially targeted nucleosides and nucleotides …