Systems biology of fungal infection

F Horn, T Heinekamp, O Kniemeyer… - Frontiers in …, 2012 - frontiersin.org
Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi,
Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the …

Systems biology approaches for host–fungal interactions: An expanding multi-omics frontier

L Culibrk, CA Croft, SJ Tebbutt - OMICS: A Journal of Integrative …, 2016 - liebertpub.com
Opportunistic fungal infections are an increasing threat for global health, and for
immunocompromised patients in particular. These infections are characterized by interaction …

Systems biology of infectious diseases: a focus on fungal infections

R Santamaría, L Rizzetto, M Bromley, T Zelante, W Lee… - Immunobiology, 2011 - Elsevier
The study of infectious disease concerns the interaction between the host species and a
pathogen organism. The analysis of such complex systems is improving with the evolution of …

[HTML][HTML] Systems biology of host–fungus interactions: turning complexity into simplicity

L Tierney, K Kuchler, L Rizzetto, D Cavalieri - Current opinion in …, 2012 - Elsevier
Modeling interactions between fungi and their hosts at the systems level requires a
molecular understanding both of how the host orchestrates immune surveillance and …

Complexity and dynamics of host–fungal interactions

F Cottier, N Pavelka - Immunologic research, 2012 - Springer
Pathologies attributable to fungal infections represent a growing concern in both developed
and developing countries. Initially discovered as opportunistic pathogens of …

Facing the challenges of multiscale modelling of bacterial and fungal pathogen–host interactions

J Schleicher, T Conrad, M Gustafsson… - Briefings in …, 2017 - academic.oup.com
Recent and rapidly evolving progress on high-throughput measurement techniques and
computational performance has led to the emergence of new disciplines, such as systems …

Friend or foe: using systems biology to elucidate interactions between fungi and their hosts

L Rizzetto, D Cavalieri - Trends in microbiology, 2011 - cell.com
Modelling the networks sustaining the fruitful coexistence between fungi and their
mammalian hosts is becoming increasingly important to control emerging fungal pathogens …

Integrated inference and evaluation of host–fungi interaction networks

CW Remmele, CH Luther, J Balkenhol… - Frontiers in …, 2015 - frontiersin.org
Fungal microorganisms frequently lead to life-threatening infections. Within this group of
pathogens, the commensal Candida albicans and the filamentous fungus Aspergillus …

A systems biological view of intracellular pathogens

DP Beiting, DS Roos - Immunological reviews, 2011 - Wiley Online Library
As biomedical research becomes increasingly data‐intensive, it is increasingly essential to
integrate genomic‐scale datasets, so as to generate a more holistic picture of complex …

Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans

JF Muñoz, T Delorey, CB Ford, BY Li… - Nature …, 2019 - nature.com
The outcome of fungal infections depends on interactions with innate immune cells. Within a
population of macrophages encountering Candida albicans, there are distinct host …