Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the
failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have …

Therapy of systemic autoimmune rheumatic diseases can still be a challenge for clinicians
despite enormous progress made in the last decades on the understanding of the …

Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the
control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is …

Autoimmune disease therapy may be considered a puzzle under construction. Current
treatments for autoimmune diseases include physical therapy, non-steroidal anti …

Drugs of unknown mechanisms of action are no longer being developed because we have
largely capitalized on our improved understanding of the immunopathogenesis of immune …

Autoimmunity refers to an organism's immune response against its own healthy cells,
tissues, or components, potentially leading to irreversible damage to vital organs. Central …

Almost all current therapeutic concepts in autoimmune diseases are based on the systemic
suppression of immune functions and are not curative. The recent introduction of biologicals …

Regulatory T cells (Tregs) play a dominant role in the regulation of immune responses.
Quantitative and/or qualitative abnormalities of Tregs were observed in patients with …

Autoimmune diseases (ADs) are primarily mediated by the failure of immunological self-
tolerance. Regulatory T cells (Tregs) play a critical role in the maintenance of induced …

Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …