RG100204, a novel Aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis

S Mohammad, CE O'riordan, C Verra… - Frontiers in …, 2022 - frontiersin.org
Sepsis is caused by systemic infection and is a major health concern as it is the primary
cause of death from infection. It is the leading cause of mortality worldwide and there are no …

Ablation of aquaporin-9 ameliorates the systemic inflammatory response of LPS-induced endotoxic shock in mouse

A Tesse, P Gena, M Rützler, G Calamita - Cells, 2021 - mdpi.com
Septic shock is the most severe complication of sepsis, being characterized by a systemic
inflammatory response following bacterial infection, leading to multiple organ failure and …

AQP3 and AQP9—Contrary Players in Sepsis?

P Thon, T Rahmel, D Ziehe, L Palmowski… - International Journal of …, 2024 - mdpi.com
Sepsis involves an immunological systemic response to a microbial pathogenic insult,
leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction …

AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

K Rump, M Unterberg, L Bergmann, A Bankfalvi… - Journal of translational …, 2016 - Springer
Background The C-allele of the aquaporin (AQP5)-1364A/C polymorphism is associated
with decreased AQP5 expression but increased 30-day survival in patients with severe …

Aquaporin 1 and 5 expression evoked by the β2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is …

K Rump, P Brendt, UH Frey, ST Schäfer, W Siffert… - Shock, 2013 - journals.lww.com
Abstract Aquaporin 1 (AQP1) and AQP5 expression may impact on key mechanisms in
sepsis. However, it is unclear whether these AQPs are expressed to an equal extent or …

Function of aquaporins in sepsis: a systematic review

K Rump, M Adamzik - Cell & bioscience, 2018 - Springer
Background Sepsis is a common cause of death in intensive care units worldwide. Due to
the high complexity of this immunological syndrome development of novel therapeutic …

Aquaporin 4 blockade attenuates acute lung injury through inhibition of Th17 cell proliferation in mice

C Guo, T Wu, H Zhu, L Gao - Inflammation, 2019 - Springer
Acute lung injury (ALI) is a syndrome characterized by damage to the alveolar-capillary wall,
pulmonary edema and recruitment of inflammatory cells. Previous studies have indicated …

Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

M Hara-Chikuma, M Tanaka, AS Verkman… - Nature …, 2020 - nature.com
Abstract Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide
(H2O2) that is expressed in various epithelial cells and in macrophages. Here, we …

Cytoprotective effect of aquaporin 1 against lipopolysaccharide‑induced apoptosis and inflammation of renal epithelial HK‑2 cells

Y Wang, W Zhang, G Yu, Q Liu… - Experimental and …, 2018 - spandidos-publications.com
Sepsis is the most common underlying disease of disseminated intravascular coagulation.
Acute kidney injury is a common and serious complications of sepsis. In the present study, a …

Role of aquaporin-3 in intestinal injury induced by sepsis

Y Zhu, Y Wang, W Teng, Y Shan, S Yi… - Biological and …, 2019 - jstage.jst.go.jp
Abstract Aquaporin-3 (AQP3) is expressed in various parts of the intestine, where it
regulates the proliferation and migration of intestinal epithelial cells and the transport of …