Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

Protein structure underlies essential biological processes and provides a blueprint for
molecular mimicry that drives drug discovery. Although small molecules represent the lion's …

Proteins that engage in intracellular interactions with other proteins are widely considered
among the most biologically appealing yet chemically intractable targets for drug discovery …

Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

Highlights•Naturally occurring peptides are important resources in order to develop
pharmaceutical lead compounds.•Natural peptides are often limited by poor stability or …

The peptide α‐helix represents one of nature's most featured protein shapes and is
employed in a diversity of protein architectures, from the cytoskeletal infrastructure to the …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to
dissect and target protein interactions. While there is consensus that stapled peptides can …

Peptides are receiving increasing interest as clinical therapeutics. These highly tunable
molecules can be tailored to achieve desirable biocompatibility and biodegradability with …