Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. In the mature brain, inhibitory GABAergic signaling is critical in maintaining …

In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia.
This begs the question: what happens in the malfunctioning brain? There are many reasons …

Excitatory-inhibitory (EI) imbalance has been shown to contribute to the pathogenesis of a
wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy …

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The
GABAergic system is indispensable for maintaining the balance between excitation and …

During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

The GABAergic system is central to the development and functional maturation of the
nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro …

In physiological conditions, the intracellular chloride concentration is much lower than the
extracellular. As GABAA channels are permeable to anions, the reversal potential of GABAA …

The imbalance between neuronal excitation and inhibition (E/I) in neural circuit has been
considered to be at the root of numerous brain disorders. We recently reported a novel …

The hippocampus is a primary area for contextual memory, known to process spatiotemporal
information within a specific episode. Long-term strengthening of glutamatergic transmission …