Activation of farnesoid X receptor by schaftoside ameliorates acetaminophen-induced hepatotoxicity by modulating oxidative stress and inflammation
M Liu, G Zhang, M Song, J Wang, C Shen… - Antioxidants & Redox …, 2020 - liebertpub.com
Aims: Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic
mitochondrial oxidative stress and inflammation. However, the molecular mechanisms …
mitochondrial oxidative stress and inflammation. However, the molecular mechanisms …
Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and …
K Liu, X Chen, Y Ren, C Liu, A Yuan, L Zheng… - Toxicology and Applied …, 2022 - Elsevier
Farnesoid X receptor (FXR), a bile acid receptor, plays an essential role in maintaining bile
acid and liver homeostasis and has been recognized as an essential target for drug-induced …
acid and liver homeostasis and has been recognized as an essential target for drug-induced …
[HTML][HTML] Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy
L Wang, W Wei, Q Xiao, H Yang, X Ci - International Journal of …, 2019 - ncbi.nlm.nih.gov
Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is
involved in the prevention of hepatotoxicity. The purpose of the current study was to explore …
involved in the prevention of hepatotoxicity. The purpose of the current study was to explore …
Xanthohumol ameliorates diet-induced liver dysfunction via farnesoid X receptor-dependent and independent signaling
The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid
(BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression …
(BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression …
Salidroside ameliorates liver metabonomics in relation to modified gut-liver FXR signaling in furan-induced mice
Y Yuan, X Wu, Y Hong, X Zhang, Z Wang… - Food and Chemical …, 2020 - Elsevier
The study aimed to investigate the ameliorative effect of salidroside (SAL) on the crosstalk
among liver metabonomics, gut barrier function and bile acids in furan-induced mice. Forty …
among liver metabonomics, gut barrier function and bile acids in furan-induced mice. Forty …
FXR ligands protect against hepatocellular inflammation via SOCS3 induction
Z Xu, G Huang, W Gong, P Zhou, Y Zhao, Y Zhang… - Cellular signalling, 2012 - Elsevier
Because of the anti-inflammatory actions of farnesoid X receptor (FXR) agonists, FXR has
received much attention as a potential therapeutic target. However, the molecular …
received much attention as a potential therapeutic target. However, the molecular …
Editor's Highlight: Farnesoid X receptor protects against low-dose carbon tetrachloride-induced liver injury through the taurocholate-JNK pathway
S Takahashi, N Tanaka, S Golla, T Fukami… - Toxicological …, 2017 - academic.oup.com
Hepatotoxicity is of major concern for humans exposed to industrial chemicals and drugs.
Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism …
Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism …
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach
Non-steroidal anti-inflammatory drugs (NSAIDs) are worldwide used drugs for analgesic,
antipyretic and anti-inflammatory therapeutics. However, NSAIDs often cause several …
antipyretic and anti-inflammatory therapeutics. However, NSAIDs often cause several …
Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
W Wu, B Zhu, X Peng, M Zhou, D Jia, J Gu - Biochemical and biophysical …, 2014 - Elsevier
Alcoholic liver disease (ALD) is a common cause of advanced liver disease, and considered
as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a …
as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a …
Obeticholic acid ameliorates valproic acid–induced hepatic steatosis and oxidative stress
Z Gai, E Krajnc, SL Samodelov, M Visentin… - Molecular …, 2020 - ASPET
Farnesoid X receptor (FXR), or NR1H4, protects the liver from insults of various etiologies. A
role of FXR in drug-induced liver injury has also been hypothesized yet only marginally …
role of FXR in drug-induced liver injury has also been hypothesized yet only marginally …