A guide to immunometabolism for immunologists

LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

[PDF][PDF] SnapShot: immunometabolism

PJ Murray, J Rathmell, E Pearce - Cell metabolism, 2015 - cell.com
Immunometabolism is a burgeoning field dissecting the contribution of key metabolic
pathways to immune cell development, fate, and behavior. This SnapShot provides an …

Driving immunity: all roads lead to metabolism

EJ Pearce, EL Pearce - Nature Reviews Immunology, 2018 - nature.com
In 2017, studies of cellular metabolism broadly permeated immunological research.
Accumulating data support the view that understanding how metabolism regulates immune …

[HTML][HTML] Immunometabolism: cellular metabolism turns immune regulator

RM Loftus, DK Finlay - Journal of Biological Chemistry, 2016 - ASBMB
Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

[HTML][HTML] Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology

H Chi - Cellular & molecular immunology, 2022 - nature.com
Metabolism is a core process underlying essentially all biological functions. The integration
of metabolism with immunity, known as immunometabolism, is at the forefront of immunology …

Metabolism in type 2 immune responses

AM Kabat, EL Pearce, EJ Pearce - Immunity, 2023 - cell.com
The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

A guide to interrogating immunometabolism

K Voss, HS Hong, JE Bader, A Sugiura… - Nature Reviews …, 2021 - nature.com
The metabolic charts memorized in early biochemistry courses, and then later forgotten,
have come back to haunt many immunologists with new recognition of the importance of …

[HTML][HTML] Metabolic regulation of immune responses: therapeutic opportunities

N Assmann, DK Finlay - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Immune cell metabolism is dynamically regulated in parallel with the substantial changes in
cellular function that accompany immune cell activation. While these changes in metabolism …

[PDF][PDF] The cellular and molecular basis of translational immunometabolism

GD Norata, G Caligiuri, T Chavakis, G Matarese… - Immunity, 2015 - cell.com
The immune response requires major changes to metabolic processes, and indeed, energy
metabolism and functional activation are fully integrated in immune cells to determine their …

Metabolic regulation of inflammation

T Gaber, C Strehl, F Buttgereit - Nature Reviews Rheumatology, 2017 - nature.com
Immune cells constantly patrol the body via the bloodstream and migrate into multiple
tissues where they face variable and sometimes demanding environmental conditions …