Background: The physiological importance of mucus plugs in computed tomography (CT)
imaging is being increasingly recognized. However, whether airway inflammation and …

Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung
scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug …

Background Mucus plugs have been described in the airways of asthmatic subjects,
particularly those with associated with type 2 inflammation and sputum eosinophilia. In the …

BACKGROUND. The link between mucus plugs and airflow obstruction has not been
established in chronic severe asthma, and the role of eosinophils and their products in …

Purpose There are reports concerning mucus plugs detected on high-resolution computed
tomography images and airflow obstruction in asthma and chronic obstructive pulmonary …

Background Mucus plugging is recognized as a contributory factor to airway obstruction and
symptoms in persistent asthma. Objective We aimed to determine phenotypic associations of …

Background Intraluminal contributor (s) to airflow obstruction in severe asthma are patient-
specific and must be evaluated to personalize treatment. The occurrence and functional …

Background Airway wall thickening and excess airway mucus occur in asthma and chronic
obstructive pulmonary disease (COPD), but few studies have investigated the relationship …

Autopsy studies in fatal asthma have clearly documented the central role of airway plugging
with pathologic mucus in the pathophysiology of death from asthma, but the role of mucus …

Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow
limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) …