Background Squamous cell carcinoma (SCC) is the most common oral malignancy, and
somatic mutations in some driver genes have been implicated in SCC development. Clear …

Salivary duct carcinoma (SDC) is an aggressive malignant tumor with a high mortality, which
resembles high‐grade breast ductal carcinoma in morphology. The parotid gland is the most …

Phosphatidylinositol 3‐kinases (PI3K) are a group of heterodimeric lipid kinases that
regulate many cellular processes. Gene amplification and somatic mutations mainly within …

Background Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha
(PIK3CA) mutations have been reported in many cancers, including head and neck …

The phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma (AKT) viral oncogene pathway
is involved in regulating the signaling of multiple biological processes such as apoptosis …

OBJECTIVES: The development of oral squamous cell carcinoma (OSCC) is a complex,
multistep process. To date, numerous oncogenes and tumor-suppressor genes have been …

Whole-exome sequencing studies showed the mutational landscape of head and neck
squamous cell carcinoma including oral cavity. Recent several reports also demonstrated …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases that regulate
cellular activities such as proliferation, survival, motility and morphology. Recent studies …

In the new age of PI3K inhibitors, the mutational status of PI3Kca oncogene in the Cavity
Squamous Cell Carcinoma (OC-SCC) needs further analysis. It is the sixth most common …

Objective Many genetic factors have been implicated in the development of oral squamous
cell carcinoma (OSCC). Although mutations associated with OSCC have been well …