[HTML][HTML] Exosomes Mediate APP Dysregulation via APP-miR-185-5p Axis
L Ding, X Yang, X Xia, Y Li, Y Wang, C Li… - Frontiers in Cell and …, 2022 - frontiersin.org
APP misexpression plays a crucial role in triggering a complex pathological cascade,
leading to Alzheimer's disease (AD). But how the expression of APP is regulated in …
leading to Alzheimer's disease (AD). But how the expression of APP is regulated in …
Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling
A Fernandes, AR Ribeiro, M Monteiro, G Garcia… - Biochimie, 2018 - Elsevier
Exosome-mediated intercellular communication has been increasingly recognized as
having a broad impact on Alzheimer's disease (AD) pathogenesis. Still, limited information …
having a broad impact on Alzheimer's disease (AD) pathogenesis. Still, limited information …
[HTML][HTML] Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes
L Chen, XY Xiong, TT Yao, LN Gui, F Luo, Y Du… - Pharmacological …, 2023 - Elsevier
The development and progression of autism spectrum disorder (ASD) is characterized by
multiple complex molecular events, highlighting the importance of the prefrontal brain …
multiple complex molecular events, highlighting the importance of the prefrontal brain …
[HTML][HTML] Exosomes derived from M2 microglia cells attenuates neuronal impairment and mitochondrial dysfunction in Alzheimer's disease through the PINK1/Parkin …
N Li, J Shu, X Yang, W Wei, A Yan - Frontiers in Cellular …, 2022 - frontiersin.org
The accumulation of abnormal aggregation of amyloid-β plaques is one of the most
distinguishing pathologies of Alzheimer's disease (AD) and is highly toxic to neurons …
distinguishing pathologies of Alzheimer's disease (AD) and is highly toxic to neurons …
The release and transmission of amyloid precursor protein via exosomes
T Zheng, X Wu, X Wei, M Wang, B Zhang - Neurochemistry International, 2018 - Elsevier
Amyloid precursor protein (APP) processing is central in Alzheimer's disease (AD)
pathogenesis. The healthy unaffected neurons suffer the transmission of amyloid protein …
pathogenesis. The healthy unaffected neurons suffer the transmission of amyloid protein …
Circulating small extracellular vesicle-derived miR-342-5p ameliorates beta-amyloid formation via targeting beta-site APP cleaving enzyme 1 in Alzheimer's disease
Z Dong, H Gu, Q Guo, X Liu, F Li, H Liu, L Sun, H Ma… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disorder with progressive
cognitive impairment in the elderly. Beta-amyloid (Aβ) formation and its accumulation in the …
cognitive impairment in the elderly. Beta-amyloid (Aβ) formation and its accumulation in the …
Exosomes and microRNAs: new potential therapeutic candidates in Alzheimer disease therapy
E Iranifar, BM Seresht, F Momeni… - Journal of cellular …, 2019 - Wiley Online Library
Exosomes are biological nanocarriers which could be involved in a variety of basic
physiological events. They exert their effects via targeting their cargos (ie, DNAs, messenger …
physiological events. They exert their effects via targeting their cargos (ie, DNAs, messenger …
Exosome-encapsulated microRNAs as promising biomarkers for Alzheimer's disease
J Chen, G Yang, Q Yan, J Zhao, S Li - Reviews in the Neurosciences, 2019 - degruyter.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that locks into long clinical
latency and low curative ratio. Therefore, early diagnosis before the clinical phase is quite …
latency and low curative ratio. Therefore, early diagnosis before the clinical phase is quite …
[HTML][HTML] Potential roles of exosomal microRNAs as diagnostic biomarkers and therapeutic application in Alzheimer's disease
J Chen, B Zhao, J Zhao, S Li - Neural plasticity, 2017 - hindawi.com
Exosomes are bilipid layer-enclosed vesicles derived from endosomes and are released
from neural cells. They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) …
from neural cells. They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) …
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play a critical
role in the development of Alzheimer's disease (AD) pathology. Aβ-containing neuronal …
role in the development of Alzheimer's disease (AD) pathology. Aβ-containing neuronal …