Metabolomics and transcriptomics joint analysis reveals altered amino acid metabolism in esophageal squamous cell carcinoma

Y Chen, H Yang, X Huang, R Wang, W Mao, Z Chen - 2023 - researchsquare.com
Objectives This study aims to explore the altered metabolic pathways for ESCC through joint-
pathway analysis of differentially expressed metabolites and genes. Methods Differentially …

Combined metabolomic analysis of plasma and tissue reveals a prognostic risk score system and metabolic dysregulation in esophageal squamous cell carcinoma

Z Chen, Y Dai, X Huang, K Chen, Y Gao, N Li… - Frontiers in …, 2020 - frontiersin.org
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy
with a poor prognosis. Although studies have shown metabolic reprogramming to be linked …

[HTML][HTML] Untargeted metabolomics analysis of esophageal squamous cell carcinoma discovers dysregulated metabolic pathways and potential diagnostic biomarkers

ZJ Zhu, Z Qi, J Zhang, WH Xue, LF Li, ZB Shen… - Journal of …, 2020 - ncbi.nlm.nih.gov
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most fatal
diseases worldwide. Because early diagnosis is difficult, ESCC is mostly diagnosed at an …

Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma

Z Chen, Y Gao, X Huang, Y Yao, K Chen… - … of Pharmaceutical and …, 2021 - Elsevier
Prognosis for esophageal squamous cell carcinoma (ESCC) is poor, so it is essential to
develop a more complete understanding of the disease. The purpose of this study was to …

Untargeted metabolomics analysis of esophageal squamous cell cancer progression

T Yang, R Hui, J Nouws, M Sauler, T Zeng… - Journal of translational …, 2022 - Springer
Abstract 90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and
ESCC has a very poor prognosis and high mortality. Nevertheless, the key metabolic …

[HTML][HTML] Integrating transcriptome and metabolome variability to reveal pathogenesis of esophageal squamous cell carcinoma

J Cheng, Q Liu, H Jin, D Zeng, Y Liao, Y Zhao… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Background Esophageal Squamous Cell Carcinoma (ESCC) is an aggressive
malignancy, leading to more than 250,000 deaths in China every year. However, the …

Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging

J Xu, Y Chen, R Zhang, J He, Y Song, J Wang… - Scientific Reports, 2016 - nature.com
We performed a metabolomics study using liquid chromatography-mass spectrometry (LC-
MS) combined with multivariate data analysis (MVDA) to discriminate global urine profiles in …

Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with a poor prognosis. Although studies have shown metabolic …

S Zeng, W Mao, Z Chen, Y Dai, X Huang… - Target Discovery for …, 2021 - books.google.com
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy
with a poor prognosis. Although studies have shown metabolic reprogramming to be linked …

Untargeted serum metabolomics reveals potential biomarkers and metabolic pathways associated with esophageal cancer

X Yang, P Wang, H Ye, M Jiang, Y Su, X Peng… - Frontiers in …, 2022 - frontiersin.org
Metabolomics has been reported as an efficient tool to screen biomarkers that are related to
esophageal cancer. However, the metabolic biomarkers identifying malignant degrees and …

[HTML][HTML] Nuclear magnetic resonance-based metabolomics and metabolic pathway networks from patient-matched esophageal carcinoma, adjacent noncancerous …

JH Liang, Y Lin, T Ouyang, W Tang… - World journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Several studies have demonstrated a correlation between esophageal
cancer (EC) and perturbed urinary metabolomic profiles, but none has described the …