Genetic testing has uncovered rare variants in complement proteins associated with
thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are …

Introduction The syndromes of thrombotic microangiopathy (TMA) are diverse and represent
severe endothelial damage caused by various mechanisms. The complement system plays …

The thrombotic microangiopathies (TMAs) and C3 glomerulopathies (C3Gs) include a
spectrum of rare diseases such as atypical hemolytic uremic syndrome, thrombotic …

Sex differences among patients with complement-gene-variant-mediated thrombotic
microangiopathy (cTMA) are not well established. We examined demographic and clinical …

The complement system, as part of the innate immune system, plays an important role in
renal transplantation. Complement is involved in the protection against foreign organisms …

The significance of rare germline mutations in transplant-associated thrombotic
microangiopathy (TA-TMA) is not well studied. We performed a genetic association study in …

Background Recently, early graft loss has become very rare in living-related kidney
transplantation (LKT) as a result of decreased risk of hyperacute rejection and improvements …

Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia and
microangiopathic hemolytic anemia, results from acute and/or chronic endothelial cell injury …

Background Genetic variation in complement genes is a predisposing factor for atypical
hemolytic uremic syndrome (aHUS), a life-threatening thrombotic microangiopathy, however …

Background Thrombotic microangiopathy (TMA) occurs in immunoglobulin A nephropathy
(IgAN), and the pathogenesis is not known behind the endothelium injury. The genetic …