Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction and
bone resorption. The proinflammatory cytokine interleukin 17 (IL‐17), primarily produced by …

Rheumatoid arthritis (RA) is a chronic, persistent inflammatory joint disease with systemic
involvement that affects about 1% of the world's population, that ultimately leads to the …

Abstract Interleukin (IL)-17 is a 30-to 35-kDa homodimeric polypeptide cytokine cloned in
1993 and originally named cytotoxic T lymphocyte-associated antigen-8 (CTLA-8) …

The prominence of T cells and monocyte/macrophages in rheumatoid synovium suggests T
cells may localize and amplify the effector functions of monocyte/macrophages in …

Objective To investigate the presence and role of interleukin‐17 (IL‐17) in rheumatoid
arthritis (RA), and its regulation by antiinflammatory cytokines. Methods The production of IL …

Interleukin-17 is a proinflammatory cytokine. Recent animal studies have shown that IL-17
plays a role in the initiation and progression of arthritis. However, whether IL-17 has a …

Rheumatoid arthritis (RA) is a chronic inflammatory disease where the contribution of T cells
is now supported by clinical results. Among the cytokines produced by T cells, interleukin …

Abstract Interleukin-17 (IL-17) is a T cell cytokine spontaneously produced by cultures of
rheumatoid arthritis (RA) synovial membranes. High levels have been detected in the …

Interleukin (IL)-17 is a T-cell-derived cytokine that is expressed in the synovium of patients
with arthritis. IL-17 contributes to the pathogenesis of arthritis, and demonstrates additive or …

The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …