Skin models of cutaneous toxicity, transdermal transport and wound repair

I Vilela de Sousa, MJS Ferreira, LB Bebiano… - Burns & …, 2023 - academic.oup.com
Skin is widely used as a drug delivery route due to its easy access and the possibility of
using relatively painless methods for the administration of bioactive molecules. However, the …

Human skin models: From healthy to disease‐mimetic systems; characteristics and applications

T Moniz, SA Costa Lima, S Reis - British journal of …, 2020 - Wiley Online Library
Skin drug delivery is an emerging route in drug development, leading to an urgent need to
understand the behaviour of active pharmaceutical ingredients within the skin. Given, As …

Skin-on-a-chip models: General overview and future perspectives

I Risueño, L Valencia, JL Jorcano, D Velasco - APL bioengineering, 2021 - pubs.aip.org
Over the last few years, several advances have been made toward the development and
production of in vitro human skin models for the analysis and testing of cosmetic and …

Skin diseases modeling using combined tissue engineering and microfluidic technologies

MH Mohammadi, B Heidary Araghi… - Advanced …, 2016 - Wiley Online Library
In recent years, both tissue engineering and microfluidics have significantly contributed in
engineering of in vitro skin substitutes to test the penetration of chemicals or to replace …

Advances in Skin-Mimetic Platforms: A Comprehensive Review of Drug Permeation Models

D Suthar, R Raut, A Bajaj - Journal of Drug Delivery Science and …, 2024 - Elsevier
In recent days, the utilization of the skin as a pathway for drug delivery has gained
substantial popularity and recognition. The skin's natural barrier properties pose a significant …

An Innovative Fluid Dynamic System to Model Inflammation in Human Skin Explants

A Galvan, E Cappellozza, Y Pellequer, A Conti… - International Journal of …, 2023 - mdpi.com
Skin is a major administration route for drugs, and all transdermal formulations must be
tested for their capability to overcome the cutaneous barrier. Therefore, developing highly …

Recent advances in in vitro skin-on-a-chip models for drug testing

JH Sung, JJ Kim - Expert Opinion on Drug Metabolism & …, 2023 - Taylor & Francis
Introduction The skin is an organ that has the largest surface area and provides a barrier
against external environment. While providing protection, it also interacts with other organs …

Current strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlook

A Bal-Öztürk, B Miccoli, M Avci-Adali… - Current …, 2018 - ingentaconnect.com
The skin is the largest and most exposed organ in the human body. Not only it is involved in
numerous biological processes essential for life but also it represents a significant endpoint …

Open-source human skin model with an in vivo-like barrier for drug testing

P Zoio, S Lopes-Ventura, J Marto, A Oliva - ALTEX-Alternatives to animal …, 2022 - altex.org
There is a global trend towards the development of physiologically relevant in vitro skin
models to reduce or replace animal testing in the evaluation of therapeutic drug candidates …

Integrated Microscopy and Metabolomics to Test an Innovative Fluid Dynamic System for Skin Explants In Vitro

E Cappellozza, S Zanzoni, M Malatesta… - Microscopy and …, 2021 - academic.oup.com
The in vitro models are receiving growing attention in studies on skin permeation,
penetration, and irritancy, especially for the preclinical development of new transcutaneous …