In complex environments, cells have developed molecular responses to confront threats
against the genome and achieve the maintenance of genomic stability assuring the transfer …

DNA damage occurs on exposure to genotoxic agents and during physiological DNA
transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions that …

The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured
signaling pathways that recognize and repair DNA damage, and the immune response to …

The DNA damage response (DDR) alerts the immune system to the danger posed by DNA
damage through the induction of damage‐associated molecular pattern molecules …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

The crosstalk between DNA repair and immune responses: Molecular Cell Skip to Main
Content Advertisement Molecular Cell This journal offers authors two options (open access or …

When cells proliferate, stress on DNA replication or exposure to endogenous or external
insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the …

The maintenance of genomic stability in multicellular organisms relies on the DNA damage
response (DDR). The DDR encompasses several interconnected pathways that cooperate …

To counteract DNA damage, cells employ genome maintenance pathways that are directed
inward, relentlessly to scan and repair the genome. Adaptive and innate immune …