Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …

Nucleoside analogues are widely used for the treament of hematological malignancies and
solid tumors. Their activity is based on the interference with cellular targets involved in the …

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine
arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) …

Cytotoxic deoxynucleoside analogues are widely used in the treatment of haematological
malignancies and solid tumours. Their metabolism and mechanisms of action are relatively …

Cytotoxic nucleoside analogues are clinically important anticancer drugs. These agents
behave as antimetabolites, compete with physiologic nucleosides, and, consequently …

Cytotoxic nucleoside analogues and nucleobases were among the first chemotherapeutic
agents to be introduced for the medical treatment of cancer. This family of compounds has …

Physiologic nucleosides and most therapeutic nucleoside analogs do not readily cross
plasma membranes by passive diffusion due to their low solubility in lipid bilayers, and their …

This chapter evaluates the metabolic and pharmacodynamic characteristics of anticancer
nucleoside analogs of major importance. It utilizes an understanding of the pharmacology …

Nucleosides exhibit a broad spectrum of biological activity that generally results from their
ability to inhibit specific enzymes. This activity has led to their use in the development of …

The nucleoside analog cytarabine (Ara-C) is an essential component of primary and salvage
chemotherapy regimens for acute myeloid leukemia (AML). After cellular uptake, Ara-C is …