One of the most important but less understood step of epithelial tumourigenesis occurs when
cells acquire the ability to leave their epithelial compartment. This phenomenon, described …

Background Many cells that migrate during normal embryonic development or in metastatic
cancer first detach from an epithelium. However, this step is often difficult to observe directly …

Metastasis is the leading cause of cancer-related deaths, but it is unclear how cancer cells
escape their primary sites in epithelia and disseminate to other sites in the body. One …

Prostatic branching morphogenesis is an intricate event requiring precise temporal and
spatial integration of numerous hormonal and growth factor-regulated inputs, yet relatively …

Polarized epithelial cells convert into migratory invasive cells during a number of
developmental processes, as well as when tumors metastasize. Much has been learned …

Prostate cancer is the most common cancer in aging men. Despite recent progress, there
are still few effective treatments to cure its aggressive and metastatic stages. A better …

Activating mutations in genes of the Ras-mitogen-activated protein kinase (MAPK) pathway
occur in approximately 30% of all human cancers; however, mutation of Ras alone is rarely …

The conversion of stationary epithelial cells into migratory, invasive cells is important for
normal embryonic development and tumour metastasis. Border-cell migration in the ovary of …

Stationary‐to‐migratory transitions of epithelial cells have a key role in development and
tumour progression. Border cell migration is a powerful system in which to investigate this …

Metastasis is the main cause of carcinoma-related death, yet we know little about how it
initiates due to our inability to visualize stochastic invasion events. Classical models suggest …