Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular …

M Wang, H Guo, B Zhang, Y Shang, S Zhang… - Cancer Cell …, 2024 - Springer
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with
a high mortality rate and poor prognosis. Mutated or dysregulated transcription factors (TFs) …

A novel transcription factor-based signature to predict prognosis and therapeutic response of hepatocellular carcinoma

Y Yang, X Ye, H Zhang, Z Lin, M Fang, J Wang… - Frontiers in …, 2023 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is one of the most common aggressive
malignancies with increasing incidence worldwide. The oncogenic roles of transcription …

Molecular subtypes based on immune-related genes predict the prognosis for hepatocellular carcinoma patients

B Hu, XB Yang, XT Sang - International immunopharmacology, 2021 - Elsevier
Background Hepatocellular carcinoma (HCC) is a malignancy exhibiting the highest
lethality. The present study aimed to identify different immune-related clusters in HCC and a …

Immune signature-based hepatocellular carcinoma subtypes may provide novel insights into therapy and prognosis predictions

Q Zheng, Q Yang, J Zhou, X Gu, H Zhou, X Dong… - Cancer cell …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) has a poor prognosis and has become the
sixth most common malignancy worldwide due to its high incidence. Advanced approaches …

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

Y Wang, Y Yang, Z Zhao, H Sun, D Luo, L Huttad… - Bmc Cancer, 2022 - Springer
Background The combined application of immune cells and specific biomarkers related to
the tumor immune microenvironment has a better predictive value for the prognosis of HCC …

Prognosis-related molecular subtypes and immune features associated with hepatocellular carcinoma

J Ye, Y Lin, X Gao, L Lu, X Huang, S Huang, T Bai… - Cancers, 2022 - mdpi.com
Simple Summary Currently, there is no effective method to detect the prognosis for
hepatocellular carcinoma (HCC). This study used bioinformatics techniques to determine …

Integrated analysis revealing a novel stemness-metabolism-related gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma

Y Wang, X Wan, S Du - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a malignant lethal tumor and both cancer stem cells
(CSCs) and metabolism reprogramming have been proven to play indispensable roles in …

[HTML][HTML] Development and validation of a prognostic and immunotherapeutically relevant model in hepatocellular carcinoma

Y Wang, Y Xie, J Ma, Y Wang… - Annals of Translational …, 2020 - ncbi.nlm.nih.gov
Background The tumor immune microenvironment is pivotal in predicting clinical outcomes
and therapeutic efficacy in cancer patients. This study aims to develop an immune prediction …

Signature construction and molecular subtype identification based on liver-specific genes for prediction of prognosis, immune activity, and anti-cancer drug sensitivity …

X Zhang, Z Xiao, X Zhang, N Li, T Sun, JZ Zhang… - Cancer Cell …, 2024 - Springer
Abstract Background Liver specific genes (LSGs) are crucial for hepatocyte differentiation
and maintaining normal liver function. A deep understanding of LSGs and their …

Large-scale transcriptome analysis identified a novel cancer driver genes signature for predicting the prognostic of patients with hepatocellular carcinoma

G Li, X Du, X Wu, S Wu, Y Zhang, J Xu… - Frontiers in …, 2021 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with high
mortality and heterogeneity. Genetic mutations caused by driver genes are important …