Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires
the cell-surface protein NINJ1. PMR releases pro-inflammatory cytoplasmic molecules …

Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR
releases intracellular molecules known as damage-associated molecular patterns (DAMPs) …

Eukaryotic cells can undergo different forms of programmed cell death, many of which
culminate in plasma membrane rupture as the defining terminal event,,,,,–. Plasma …

Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It
allows the extracellular release of damage-associated molecular patterns (DAMPs) that …

First recognized more than 30 years ago, glycine protects cells against rupture from diverse
types of injury. This robust and widely observed effect has been speculated to target a late …

Inflammatory processes that recruit leukocytes to injured or infected tissues are crucial for
tissue repair and the elimination of pathogens. However, excessive or chronic inflammation …

Ferroptosis is a regulated form of necrotic cell death caused by iron-dependent
accumulation of oxidized phospholipids in cellular membranes, culminating in plasma …

Background & Aims c-Jun N-terminal kinase (JNK) 1 and JNK2 are expressed in
hepatocytes and have overlapping and distinct functions. JNK proteins are activated via …

IκB kinase β (IKKβ) is required for NF-κB activation and suppression of TNFα-mediated liver
apoptosis. To investigate how IKKβ suppresses apoptosis, we generated hepatocyte …

Based on the essential involvement of NF-κB in immune and inflammatory responses and its
apoptosis-rescue function in normal and malignant cells, inhibitors of this transcription factor …