Recent advances in medical genetics elucidated the background of diseases characterized
by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led …

Classifying inflammatory skin diseases is challenging, especially for the expanding group of
disorders triggered by genetic factors resulting in hyperactivated innate immunity that result …

Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing
diseases with a genetic background and mixed pathogenic mechanisms of …

“Autoinflammatory disease (AiD)” has first been introduced in 1999 when the responsible
gene for the familial Hibernean fever or autosomal dominant-type familial Mediterranean …

As predisposing factors and pathogenic mechanisms of inflammatory keratinization
disorders of the skin have become increasingly elucidated in recent years, a number of …

Inflammation caused by the hyper-activation of innate immunity due to genetic factors
occasionally leads to inflammatory keratinization diseases of the skin. Such inflammatory …

Pustular psoriasis is a chronic inflammatory skin disease characterized by erythematous
plaques with sterile pustules. It includes the distinct clinical entities generalized pustular …

Among the genetic causes/predisposing factors for inflammatory keratinization disorders,
several factors are associated with autoinflammatory mechanisms. Here we review these …

The hyper-activation of innate immunity caused by genetic factors sometimes results in skin
inflammatory diseases with hyperkeratosis. Such cutaneous inflammatory disorders whose …

Objectives Here we investigated a patient with inflammatory corneal intraepithelial
dyskeratosis, mucosal inflammation, tooth abnormalities and, eczema to uncover the genetic …