Abstract Introduction Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …

Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including
and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes …

Objective Polygenic risk scores (PRSs) assess the individual genetic propensity to a
condition by combining sparse information scattered across genetic loci, often displaying …

Background Polygenic scores are a strategy to aggregate the small, additive effects of single
nucleotide polymorphisms across the genome. With phenotypes like Alzheimer's disease …

Several recent case-control studies have examined the association between single
nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein E gene …

Background: The APOE ɛ4 allele is the largest genetic risk factor for late-onset Alzheimer's
disease (AD). Recent literature suggested that the contribution of APOE ɛ4 to AD risk could …

Background The combinatorial effect of multiple genetic factors calculated as a polygenic
risk score (PRS) has been studied to predict disease progression to Alzheimer's disease …

Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's
disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old …

Background: With the exception of APOE, genetic variants associated with increased
Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores …

Evidence on whether genetic predictors of Alzheimer disease (AD) also predict memory
decline is inconsistent, and limited data are available for African ancestry populations. For …