[HTML][HTML] A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive …
Abstract Introduction Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including
and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes …
and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes …
Polygenic risk score for Alzheimer's disease in Caribbean Hispanics
Objective Polygenic risk scores (PRSs) assess the individual genetic propensity to a
condition by combining sparse information scattered across genetic loci, often displaying …
condition by combining sparse information scattered across genetic loci, often displaying …
[HTML][HTML] Considering the APOE locus in Alzheimer's disease polygenic scores in the Health and Retirement Study: a longitudinal panel study
Background Polygenic scores are a strategy to aggregate the small, additive effects of single
nucleotide polymorphisms across the genome. With phenotypes like Alzheimer's disease …
nucleotide polymorphisms across the genome. With phenotypes like Alzheimer's disease …
Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease
KK Nicodemus, JE Stenger, DE Schmechel… - Neurogenetics, 2004 - Springer
Several recent case-control studies have examined the association between single
nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein E gene …
nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein E gene …
Characterizing clinical and neuropathological traits of APOE haplotypes in African Americans and Europeans
AM Mezlini, C Magdamo, E Merrill… - Journal of …, 2020 - content.iospress.com
Background: The APOE ɛ4 allele is the largest genetic risk factor for late-onset Alzheimer's
disease (AD). Recent literature suggested that the contribution of APOE ɛ4 to AD risk could …
disease (AD). Recent literature suggested that the contribution of APOE ɛ4 to AD risk could …
[HTML][HTML] Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment
Background The combinatorial effect of multiple genetic factors calculated as a polygenic
risk score (PRS) has been studied to predict disease progression to Alzheimer's disease …
risk score (PRS) has been studied to predict disease progression to Alzheimer's disease …
Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives
J Najar, SJ van der Lee, E Joas… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's
disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old …
disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old …
Utility of an Alzheimer's disease risk-weighted polygenic risk score for predicting rates of cognitive decline in preclinical Alzheimer's disease: a prospective …
Background: With the exception of APOE, genetic variants associated with increased
Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores …
Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores …
Using an Alzheimer disease polygenic risk score to predict memory decline in black and white Americans over 14 years of follow-up
Evidence on whether genetic predictors of Alzheimer disease (AD) also predict memory
decline is inconsistent, and limited data are available for African ancestry populations. For …
decline is inconsistent, and limited data are available for African ancestry populations. For …
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