Selected cytokine pathways in rheumatoid arthritis

M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

Joint inflammation and cytokine inhibition in rheumatoid arthritis

C Christodoulou, EH Choy - Clinical and experimental medicine, 2006 - Springer
The hallmark of rheumatoid arthritis (RA) is chronic synovial inflammation resulting in
progressive joint damage. Cytokines are key mediators of inflammation and can be found in …

Emerging cytokine targets in rheumatoid arthritis

DL Asquith, IB McInnes - Current opinion in rheumatology, 2007 - journals.lww.com
Novel cytokine activities are emerging on an ongoing basis. There remain difficulties in
ascribing the optimal regulatory hierarchy for given moieties on the basis of existing …

Therapeutic targets for rheumatoid arthritis: Progress and promises

A Alghasham, Z Rasheed - Autoimmunity, 2014 - Taylor & Francis
Recent therapeutic advancements in understanding of molecular and cellular mechanisms
of rheumatoid arthritis (RA) have highlighted the strategies that aim to inhibit the harmful …

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Z Chen, A Bozec, A Ramming, G Schett - Nature Reviews …, 2019 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

The biological and clinical importance of the'new generation'cytokines in rheumatic diseases

C Gabay, IB McInnes - Arthritis research & therapy, 2009 - Springer
A better understanding of cytokine biology over the last two decades has allowed the
successful development of cytokine inhibitors against tumour necrosis factor and interleukin …

An update on the cytokine network in rheumatoid arthritis

P Miossec - Current opinion in rheumatology, 2004 - journals.lww.com
An update on the cytokine network in rheumatoid arthritis : Current Opinion in Rheumatology
An update on the cytokine network in rheumatoid arthritis : Current Opinion in Rheumatology …

Cytokine networks—towards new therapies for rheumatoid arthritis

IB McInnes, FY Liew - Nature clinical practice Rheumatology, 2005 - nature.com
Success achieved so far in the blockade of tumor necrosis factor and interleukin (IL)-1 in
rheumatoid arthritis exemplifies the feasibility and potential therapeutic application of …

Pathogenesis of rheumatoid arthritis: targeting cytokines

J Zwerina, K Redlich, G Schett… - Annals of the New York …, 2005 - Wiley Online Library
Although considerable progress has been made by adequate treatment with traditional
disease‐modifying antirheumatic drugs (DMARDs), therapy of rheumatoid arthritis (RA) still …

Cytokine expression and cell activation in inflammatory arthritis

LB Ivashkiv - Advances in immunology, 1996 - Elsevier
Publisher Summary This chapter focuses upon the expression and role of cytokines in
rheumatoid arthritis (RA) that is one of the most intensively studied and best characterized …