Background Knee osteoarthritis (OA) is one of the most common structural OA disorders
globally. Incomplete understanding of the fundamental biological aspects of osteoarthritis …

Osteoarthritis is a disease that impacts millions around the world, leading to significant
financial and medical burden for patients and the healthcare system. However, no effective …

Purpose: Chondrocytes rely primarily on glycolysis to meet their energy requirements, but
possess the metabolic flexibility to support cell survival and matrix synthesis during periods …

Objective Exercise is vital for maintaining cartilage integrity in healthy joints. Here we
examined the exercise-driven transcriptional regulation of genes in healthy rat articular …

Articular cartilage function depends on the temporal and zonal distribution of coordinated
metabolic regulation in chondrocytes. Emerging evidence shows the importance of cellular …

Objective The objectives of this study was to establish a sensitive and reproducible method
to map the cartilage and subchondral bone proteomes in quantitative terms, and mine the …

Osteoarthritis (OA) is a progressive disorder with high incidence in the ageing human
population that still has no treatment currently. This disorder induces the breakdown of …

Objectives Metabolic pathways are a series of chemical reactions by which cells take in
nutrient substrates for energy and building blocks needed to maintain critical cellular …

Background The underlying molecular characteristics of osteoarthritis (OA), a common age-
related joint disease, remains elusive. Here, we aimed to identify potential early diagnostic …

In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic
activity, which leads to cartilage degradation. To enable the semiquantitative interpretation …