Context.—Identification of the site of origin of carcinoma of unknown primary using
immunohistochemistry is a frequent requirement of anatomic pathologists. Diagnostic …

This review summarizes how sophisticated imaging, immunohistochemical testing, and
molecular-profiling tools are changing the approach to cancer of unknown primary site …

The management of patients with unknown primary carcinoma (UPC) has evolved over the
last few years and the recently developed sophisticated diagnostic modalities and novel …

Background Molecular tumor profiling (MTP) is a potentially powerful diagnostic tool for
identifying the tissue of origin in patients with cancer of unknown primary (CUP). However …

The pathologic approach to metastases of unknown primary cancer (UPC) is stepwise and
uses the clinical context, morphology, and, where necessary, immunohistochemistry (IHC) …

Carcinoma of unknown primary (CUP) remains a common and challenging clinical problem.
The aim of diagnostic work-up in CUP is to classify as specifically as possible the cancer …

Cancer of unknown primary site is a histologically confirmed cancer which is manifested in
advanced stage, with no identifiable primary site after the use of standard diagnostic …

Immunohistochemistry has become an essential ancillary examination for the identification
and classification of carcinomas of unknown primary site (CUPs). Over the last decade, the …

Context.—Advances in interventional technology have enhanced the ability to safely sample
deep-seated suspicious lesions by fine-needle aspiration procedures. These procedures …

Carcinoma of unknown primary (CUP) is a diverse group of heterogeneous cancers
presenting without a primary site and accounts for about 2% to 4% of all cancers. The past …