Programmed cell death in asthma: apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis

L Liu, L Zhou, LL Wang, PD Zheng… - Journal of …, 2023 - Taylor & Francis
Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a
global health issue. A comprehensive understanding of the different molecular mechanisms …

[HTML][HTML] Ferroptosis, novel therapeutics in asthma

X Lv, M Dong, W Tang, J Qin, W Wang, M Li… - Biomedicine & …, 2022 - Elsevier
Ferroptosis, an iron-dependent form of regulated cell death, was recently demonstrated to
be closely associated with the immune system. Regulators of ferroptosis may be the cells …

[HTML][HTML] Programmed cell death in the epithelial cells of the nasal mucosa in allergic rhinitis

Y Li, L Sun, Y Zhang - International Immunopharmacology, 2022 - Elsevier
In AR, the epithelial barrier composed of Nasal epithelial cells is the first line of defense,
which is crucial to protect the host immune system from harmful stimuli. Moreover …

[HTML][HTML] Pyroptosis in inflammation-related respiratory disease

Y Feng, M Li, X Yangzhong, X Zhang, A Zu… - Journal of physiology …, 2022 - Springer
Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …

Cell death in the lung: the apoptosis–necroptosis axis

M Sauler, IS Bazan, PJ Lee - Annual review of physiology, 2019 - annualreviews.org
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

[HTML][HTML] Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence

K Sachdeva, DC Do, Y Zhang, X Hu, J Chen… - Frontiers in …, 2019 - frontiersin.org
Environmental pollutants and allergens induce oxidative stress and mitochondrial
dysfunction, leading to key features of allergic asthma. Dysregulations in autophagy …

[HTML][HTML] The link between ferroptosis and airway inflammatory diseases: A novel target for treatment

Z Lin, X Yang, L Guan, L Qin, J Ding… - Frontiers in Molecular …, 2022 - frontiersin.org
Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid
peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell …

[HTML][HTML] Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2. 5-induced asthma exacerbation

Y Zhang, M Jiang, Y Xiong, L Zhang, A Xiong… - International …, 2023 - Elsevier
Background PM2. 5 exposure increases asthma exacerbation risk and worsens airway
inflammation and mucus secretion, but the underlying mechanisms, especially the …

[HTML][HTML] Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1

L Ma, Y He, H Xie, J Wang, J Chen, S Song… - Cell Death …, 2024 - nature.com
Asthma is a common allergic disease characterized by airway hypersensitivity and airway
remodeling. Ferroptosis is a regulated death marked by iron accumulation and lipid …

Regulation of ferroptosis and ACSL4-15LO1 pathway contributed to the anti-asthma effect of acupuncture

W Tang, J Qin, Y Zhou, W Wang, F Teng, J Liu… - International …, 2023 - Elsevier
Acupuncture has been frequently used in China for the treatment asthma for thousands of
years. Ferroptosis was recently revealed to be involved in several pathological conditions …