Towards Improving Embryo Selection: Simultaneous Next Generation Sequencing Of DNA And RNA From A Single Trophectoderm Biopsy

NF Weizman, BA Wyse, R Antes, Z Ibarrientos… - bioRxiv, 2018 - biorxiv.org
Improved embryo selection is crucial in optimizing the results from assisted reproduction.
Preimplantation genetic screening reduces time to pregnancy and miscarriages. Correlating …

Towards improving embryo prioritization: parallel next generation sequencing of DNA and RNA from a single trophectoderm biopsy

N Fuchs Weizman, BA Wyse, R Antes, Z Ibarrientos… - Scientific reports, 2019 - nature.com
Improved embryo prioritization is crucial in optimizing the results in assisted reproduction,
especially in light of increasing utilization of elective single embryo transfers. Embryo …

BEYOND CHROMOSOMAL ABERRATIONS–TRANSCRIPTOMIC PROFILES OF ANEUPLOID, MOSAIC, AND EUPLOID EMBRYOS FROM TROPHECTODERM …

S Madjunkova, B Wyse, NF Weizman, R Kharonsky… - Fertility and …, 2022 - fertstert.org
Objective The effects of aberrant chromosome dosage on gene expression and the
mechanisms that regulate the transcriptional processes in preimplantation embryos are …

Concurrent genome and transcriptome analysis from a single trophectoderm biopsy

HR Chiang, JD Kort, BR Behr, MP Snyder - Fertility and Sterility, 2017 - fertstert.org
Background Trophectoderm biopsy and subsequent DNA-sequencing has been used
clinically to study the genome of human embryos, particularly for characterizing embryo …

[PDF][PDF] Deep impact: sequencing embryo biopsy specimens at increasing depth

K Spath, D Wells - Reproductive BioMedicine Online, 2015 - ora.ox.ac.uk
Despite major advances in assisted reproductive technologies (ARTs), it remains the case
that more than half of all in vitro fertilisation (IVF) treatments do not ultimately result in the …

Experience analysing over 190,000 embryo trophectoderm biopsies using a novel FAST-SeqS preimplantation genetic testing assay

L Walters-Sen, D Neitzel, SL Bristow… - Reproductive …, 2022 - rbmojournal.com
Abstract Research question Is FAST-SeqS an accurate methodology for preimplantation
genetic testing for whole-chromosome aneuploidy (PGT-A)? What additional types of …

Transcriptomic signatures in trophectoderm and inner cell mass of human blastocysts with different expectations of pregnancy

Y Kai, H Mei, H Kawano, N Nakajima, A Takai… - 2022 - researchsquare.com
Selection of high-quality embryos is important to achieve successful pregnancy in assisted
reproductive technology (ART). Recently, it has been debated whether RNA-sequencing …

THE CONCORDANCE RATES OF AN INITIAL TROPHECTODERM BIOPSY WITH THE REST OF THE EMBRYO USING PGTSEQ, A TARGETED NEXT-GENERATION …

JG Kim, X Tao, M Cheng, T Zhao, AD Steward… - Fertility and …, 2021 - fertstert.org
Objective To determine the nature of chromosomal and sub-chromosomal errors occurring
in human embryos, and how those abnormalities may impact interpretation of PGT-A results …

Transcriptomic signatures in trophectoderm and inner cell mass of human blastocysts classified according to developmental potential, maternal age and morphology

Y Kai, H Mei, H Kawano, N Nakajima, A Takai… - PLoS …, 2022 - journals.plos.org
Selection of high-quality embryos is important to achieve successful pregnancy in assisted
reproductive technology (ART). Recently, it has been debated whether RNA-sequencing …

Can trophectoderm RNA analysis predict human blastocyst competency?

P Ntostis, G Kokkali, D Iles, J Huntriss… - Systems Biology in …, 2019 - Taylor & Francis
ABSTRACT A systematic review of the literature showed that trophectoderm biopsy could
assist in the selection of healthy embryos for uterine transfer without affecting implantation …