NAD+ metabolism, stemness, the immune response, and cancer

LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

NAD+: a modulator of immune functions

A Grahnert, A Grahnert, C Klein, E Schilling… - Innate …, 2011 - journals.sagepub.com
Latterly, nicotinamide adenine dinucleotide (NAD+) has emerged as a molecule with
versatile functions and of enormous impact on the maintenance of cell integrity. Besides …

NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns

H Massudi, R Grant, GJ Guillemin, N Braidy - Redox Report, 2012 - Taylor & Francis
In the twentieth century, NAD+ research generated multiple discoveries. Identification of the
important role of NAD+ as a cofactor in cellular respiration and energy production was …

NAD+ metabolism and its roles in cellular processes during ageing

AJ Covarrubias, R Perrone, A Grozio… - Nature reviews Molecular …, 2021 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

NAD+ in aging: molecular mechanisms and translational implications

EF Fang, S Lautrup, Y Hou, TG Demarest… - Trends in molecular …, 2017 - cell.com
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …

Roles of NAD+ in Health and Aging

S Lautrup, Y Hou, EF Fang… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …

Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies

Y Zhu, J Liu, J Park, P Rai, RG Zhai - Pharmacology & therapeutics, 2019 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways

S Amjad, S Nisar, AA Bhat, MP Frenneaux, K Fakhro… - Molecular …, 2021 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

[HTML][HTML] Evolving concepts in NAD+ metabolism

CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …

NAD+ salvage pathway in cancer metabolism and therapy

BE Kennedy, T Sharif, E Martell, C Dai, Y Kim… - Pharmacological …, 2016 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …