Delivery of peptides by the oral route greatly appeals due to commercial, patient
convenience and scientific arguments. While there are over 60 injectable peptides marketed …

Therapeutic peptides have become very successful drugs due to their specificity, potency
and low toxicity, but they show challenges for their delivery, due to their short half-life and …

Oral delivery of peptide therapeutics as a convenient alternate to injections has been an
area of research for the pharmaceutical scientific community for the last several decades …

Introduction: Pharmaceutical research and development is increasingly focussed on
biopharmaceuticals including peptide and protein drugs. Despite their growing importance …

Highlights•Oral route of administration is the preferred route for drug delivery.•Dosage form
designing plays an essential role in oral peptide delivery.•Preclinical and clinical aspects of …

Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

Leila N Hassani, Andy Lewis and Joël Richard provide an overview of the advantages
provided, and challenges faced, by oral peptide delivery, and discuss the strengths and …

Clinical development of orally active peptide drugs has been restricted by their unfavorable
physicochemical properties, which limit their intestinal mucosal permeation and their lack of …

Highlights•The market for peptide drugs is constantly growing.•Oral peptide drugs in clinical
trials target severe indications.•Nanoparticles and micelles improve oral bioavailability of …

Most peptide and protein drugs are currently used as parenteral formulations because of
their poor oral bioavailability. Development of an effective oral delivery system for these …