[HTML][HTML] Augmenting azoles with drug synergy to expand the antifungal toolbox
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
Combinatorial strategies for combating invasive fungal infections
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …
particularly for immunocompromised populations. However, there remains a paucity of …
New antifungal strategies: drug combination and co-delivery
P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …
resistance constitute a significant menace to human health. Antifungal drug combinations …
New facets of antifungal therapy
Invasive fungal infections remain a major cause of morbidity and mortality in
immunocompromised patients, and such infections are a substantial burden to healthcare …
immunocompromised patients, and such infections are a substantial burden to healthcare …
Combination treatment of invasive fungal infections
PK Mukherjee, DJ Sheehan, CA Hitchcock… - Clinical microbiology …, 2005 - Am Soc Microbiol
The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …
availability of novel antifungals points to the need for effective treatment strategies …
Combination antifungal therapy
MD Johnson, C MacDougall… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …
renewed interest in combination antifungal therapies. In particular, and despite the limited …
[HTML][HTML] Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …
along with significant agricultural crop loss caused by various fungal species, has resulted in …
[HTML][HTML] Current antimycotics, new prospects, and future approaches to antifungal therapy
G Wall, JL Lopez-Ribot - Antibiotics, 2020 - mdpi.com
Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …
Antifungals: mechanism of action and resistance, established and novel drugs
NH Georgopapadakou - Current opinion in microbiology, 1998 - Elsevier
Serious fungal infections, caused mostly by opportunistic species, are increasingly common
in immunocompromised and other vulnerable patients. The use of antifungal drugs, primarily …
in immunocompromised and other vulnerable patients. The use of antifungal drugs, primarily …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …