[HTML][HTML] Augmenting azoles with drug synergy to expand the antifungal toolbox

A Kane, DA Carter - Pharmaceuticals, 2022 - mdpi.com
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

Combinatorial strategies for combating invasive fungal infections

M Spitzer, N Robbins, GD Wright - Virulence, 2017 - Taylor & Francis
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

New antifungal strategies: drug combination and co-delivery

P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

New facets of antifungal therapy

YL Chang, SJ Yu, J Heitman, M Wellington, YL Chen - Virulence, 2017 - Taylor & Francis
Invasive fungal infections remain a major cause of morbidity and mortality in
immunocompromised patients, and such infections are a substantial burden to healthcare …

Combination treatment of invasive fungal infections

PK Mukherjee, DJ Sheehan, CA Hitchcock… - Clinical microbiology …, 2005 - Am Soc Microbiol
The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …

Combination antifungal therapy

MD Johnson, C MacDougall… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …

[HTML][HTML] Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

[HTML][HTML] Current antimycotics, new prospects, and future approaches to antifungal therapy

G Wall, JL Lopez-Ribot - Antibiotics, 2020 - mdpi.com
Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …

Antifungals: mechanism of action and resistance, established and novel drugs

NH Georgopapadakou - Current opinion in microbiology, 1998 - Elsevier
Serious fungal infections, caused mostly by opportunistic species, are increasingly common
in immunocompromised and other vulnerable patients. The use of antifungal drugs, primarily …

Antifungal drugs: the current armamentarium and development of new agents

N Robbins, GD Wright, LE Cowen - Microbiology spectrum, 2016 - Am Soc Microbiol
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …