Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells

LA Gilad, T Bresler, J Gnainsky… - Journal of …, 2005 - joe.bioscientifica.com
We previously demonstrated that 17β-estradiol (E2) regulates the transcription and
expression of the vitamin D receptor (VDR) in rat colonocytes and duodenocytes in vivo. The …

Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells

LA Gilad, O Tirosh, B Schwartz - Journal of endocrinology, 2006 - joe.bioscientifica.com
The present study assesses the effects of two isoflavones, genistein and glycitein, and equol–
a product of intestinal bacterial metabolism of dietary isoflavones, on vitamin D receptor …

Association of estrogen receptor β with plasma-membrane caveola components: Implication in control of vitamin D receptor

LA Gilad, B Schwartz - Journal of molecular endocrinology, 2007 - jme.bioscientifica.com
This study was designed to provide a direct demonstration of the importance of caveolin-1 in
the compartmentalization of estrogen receptor β (ERβ) to the membrane, thus allowing 7β …

Transrepression of the estrogen receptor promoter by calcitriol in human breast cancer cells via two negative vitamin D response elements

S Swami, AV Krishnan, L Peng… - Endocrine-Related …, 2013 - erc.bioscientifica.com
Calcitriol (1, 25-dihydroxyvitamin D 3), the hormonally active metabolite of vitamin D, exerts
its anti-proliferative activity in breast cancer (BCa) cells by multiple mechanisms including …

Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites

JA Wietzke, EC Ward, J Schneider, JE Welsh - Molecular and cellular …, 2005 - Elsevier
1, 25-Dihydroxyvitamin D3 (1, 25 (OH) 2D3), the active form of Vitamin D, mediates gene
transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple …

Regulation of estrogen receptor‐α gene expression by 1, 25‐dihydroxyvitamin D in MCF‐7 cells

A Stoica, M Saceda, A Fakhro… - Journal of cellular …, 1999 - Wiley Online Library
This report describes an investigation of the role of 1, 25‐dihydroxyvitamin D (VD3) in the
regulation of estrogen receptor‐α (ER) in the ER‐positive breast cancer cell line, MCF‐7 …

Phytoestrogen regulation of a Vitamin D3 receptor promoter and 1, 25-dihydroxyvitamin D3 actions in human breast cancer cells

JA Wietzke, JE Welsh - The Journal of steroid biochemistry and molecular …, 2003 - Elsevier
1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3), a steroid hormone derived from Vitamin D3, is a
negative growth regulator of breast cancer cells, and Vitamin D3 analogs represent a novel …

1α,25-Dihydroxyvitamin D3 Down-Regulates Estrogen Receptor Abundance and Suppresses Estrogen Actions in MCF-7 Human Breast Cancer Cells

S Swami, AV Krishnan, D Feldman - Clinical Cancer Research, 2000 - AACR
Abstract 1α, 25-Dihydroxyvitamin D3 [1, 25 (OH) 2D3], the active metabolite of vitamin D, is a
potent inhibitor of breast cancer cell growth. Because the estrogen receptor (ER) plays a key …

Expression Profiling in Squamous Carcinoma Cells Reveals Pleiotropic Effects of Vitamin D3 Analog EB1089 Signaling on Cell Proliferation, Differentiation, and …

R Lin, Y Nagai, R Sladek, Y Bastien, J Ho… - Molecular …, 2002 - academic.oup.com
The active form of vitamin D3, 1α, 25-dihydroxyvitamin D3 [1, 25-(OH) 2D3] is key mediator
of calcium homeostasis and is a component of the complex homeostatic system of the skin …

1α, 25 (OH) 2-Vitamin D3 stimulates intestinal cell p38 MAPK activity and increases c-Fos expression

VG Pardo, R Boland, AR de Boland - The International Journal of …, 2006 - Elsevier
In intestinal cells, as in other target cells, the steroid hormone 1α, 25 (OH) 2-Vitamin D3 (1α,
25 (OH) 2D3) regulates gene expression via the specific intracellular Vitamin D receptor and …