Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review

J Saravia, GI Lee, S Lomnicki… - … of biochemical and …, 2013 - Wiley Online Library
The health impacts of airborne particulate matter (PM) are of global concern, and the direct
implications to the development/exacerbation of lung disease are immediately obvious. Most …

Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs

JKW Chan, JG Charrier, SD Kodani, CF Vogel… - Particle and fibre …, 2013 - Springer
Background Urban particulate matter (PM) has been epidemiologically correlated with
multiple cardiopulmonary morbidities and mortalities, in sensitive populations. Children …

Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

S Jaligama, J Saravia, D You, N Yadav, GI Lee… - Respiratory …, 2017 - Springer
Background Exposure to elevated levels of particulate matter (PM) is associated with
increased risk of morbidity and mortality due to respiratory tract viral infections in infants …

Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection

GI Lee, J Saravia, D You, B Shrestha… - Particle and fibre …, 2014 - Springer
Background Exposures to elevated levels of particulate matter (PM) enhance severity of
influenza virus infection in infants. The biological mechanism responsible for this …

Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs

JKW Chan, MV Fanucchi, DS Anderson… - Toxicological …, 2011 - academic.oup.com
Over a quarter of the US population is exposed to harmful levels of airborne particulate
matter (PM) pollution, which has been linked to development and exacerbation of respiratory …

Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs

S Balakrishna, J Saravia, P Thevenot, T Ahlert… - Particle and fibre …, 2011 - Springer
Background Increased asthma risk/exacerbation in children and infants is associated with
exposure to elevated levels of ultrafine particulate matter (PM). The presence of a newly …

Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells

PT Thevenot, J Saravia, N Jin, JD Giaimo… - American journal of …, 2013 - atsjournals.org
Environmentally persistent free radicals (EPFRs) in combustion-generated particulate matter
(PM) are capable of inducing pulmonary pathologies and contributing to the development of …

Maternal exposure to combustion generated PM inhibits pulmonary Th1 maturation and concomitantly enhances postnatal asthma development in offspring

P Wang, D You, J Saravia, H Shen… - Particle and fibre …, 2013 - Springer
Background Epidemiological studies suggest that maternal exposure to environmental
hazards, such as particulate matter, is associated with increased incidence of asthma in …

In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles

B Fahmy, L Ding, D You, S Lomnicki, B Dellinger… - Environmental …, 2010 - Elsevier
Strong correlations exist between exposure to PM2. 5 and adverse pulmonary effects. PM2.
5 consists of fine (≤ 2.5 μm) and ultrafine (≤ 0.1 μm) particles with ultrafine particles …

Air pollution and children's health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter

NM Johnson, AR Hoffmann, JC Behlen, C Lau… - … health and preventive …, 2021 - Springer
Background Particulate matter (PM), a major component of ambient air pollution, accounts
for a substantial burden of diseases and fatality worldwide. Maternal exposure to PM during …