Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …

Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

The delivery of nucleic acids with transient activity for genetic engineering is a promising
methodology with potential applications in the treatment of diseases ranging from cancer …

Nanoparticles are regarded as promising transfection reagents for effective and safe
delivery of nucleic acids into a specific type of cells or tissues providing an alternative …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

The discovery of the genetic roots of various human diseases has motivated the exploration
of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders …

The last years have witnessed an impressive development of material sciences following the
burst of nanotechnology, which has greatly contributed to the development of nonviral gene …

Conspectus The outbreak of the coronavirus disease 2019 (COVID-19) pandemic and swift
approval of two mRNA vaccines have put nucleic acid therapeutics in the spotlight of both …

Nanotechnology research over the past several decades has been aimed primarily at
improving the physicochemical properties of small molecules to produce druggable …