[HTML][HTML] Exploring the promise of flavonoids to combat neuropathic pain: from molecular mechanisms to therapeutic implications

MS Uddin, AA Mamun, MA Rahman, MT Kabir… - Frontiers in …, 2020 - frontiersin.org
Neuropathic pain (NP) is the result of irregular processing in the central or peripheral
nervous system, which is generally caused by neuronal injury. The management of NP …

[HTML][HTML] In vitro and in vivo effects of flavonoids on peripheral neuropathic pain

P Basu, A Basu - Molecules, 2020 - mdpi.com
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It
is caused by the lesion or disease of the somatosensory system. Neuropathic pain …

Flavonoids in the treatment of neuropathic pain

PN Rao, O Mainkar, N Bansal, N Rakesh… - Current pain and …, 2021 - Springer
Abstract Purpose of Review Chronic pain continues to present a large burden to the US
healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly …

[HTML][HTML] Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020 - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

[HTML][HTML] Application of plant secondary metabolites to pain neuromodulation

RK Singla, AG Guimarães, G Zengin - Frontiers in Pharmacology, 2021 - frontiersin.org
Pain is a highly unpleasant and intolerable condition, which is associated with multiple
diseases and disorders, including but not limited to cancer, diabetes, infectious diseases …

Flavonoids as potential therapeutic agents for the management of diabetic neuropathy

A Sood, B Kumar, SK Singh, P Prashar… - Current …, 2020 - ingentaconnect.com
Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic
compounds are classified into various subgroups based on their structures: flavones …

[HTML][HTML] Efficacy of a combination of N-palmitoylethanolamide, beta-caryophyllene, carnosic Acid, and myrrh extract on chronic neuropathic pain: a preclinical study

Y Fotio, A Aboufares El Alaoui, AM Borruto… - Frontiers in …, 2019 - frontiersin.org
Neuropathic pain (NP) is a common public health problem that poses a major challenge to
basic scientists and health-care providers. NP is a complex problem with an unclear etiology …

Frankincense-Myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4/MyD88 pathway and TRPV1 signaling

Y Liao, C Guo, A Wen, M Bai, Z Ran, J Hu, J Wang… - Phytomedicine, 2023 - Elsevier
Background Neuroglia are important modulators of neuronal functionality, and thus play an
integral role in the pathogenesis and treatment of neuropathic pain (NP). According to …

[HTML][HTML] The emerging role of quercetin in the treatment of chronic pain

C Liu, DQ Liu, YK Tian, W Mei, XB Tian… - Current …, 2022 - ncbi.nlm.nih.gov
Despite much research efforts being devoted to designing alternative pharmacological
interventions, chronic pain remains to be an unresolved clinical problem. Quercetin, a …

[HTML][HTML] Flavonoids alleviate peripheral neuropathy induced by anticancer drugs

M Siddiqui, B Abdellatif, K Zhai, A Liskova, P Kubatka… - Cancers, 2021 - mdpi.com
Simple Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating
condition that severely reduces the quality of life of a considerable proportion of cancer …