Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial
respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle
mitochondrial respiration. Therefore, the present study examined mitochondrial respiratory …

Little is known about vascular mitochondrial respiratory function and the impact of age.
Therefore, skeletal muscle feed arteries were harvested from young (33±7 yr, n= 10), middle …

Key points The development of age‐related arterial endothelial dysfunction, a key
antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced …

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries,
which causes claudication. This may be in part due to vascular mitochondrial dysfunction …

Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Excessive reactive oxygen species production by mitochondria (mtROS) is a key contributor
to age-related vascular endothelial dysfunction. We recently showed in a crossover design …

Cardiovascular disease risk factors, such as diabetes, hypertension, dyslipidemia, obesity,
and physical inactivity, are all correlated with impaired endothelial nitric oxide synthase …

Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS)
production is a key source of oxidative stress in aging arteries that reduces baseline function …