The role of EREG/EGFR pathway in tumor progression
WL Cheng, PH Feng, KY Lee, KY Chen… - International journal of …, 2021 - mdpi.com
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …
Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer
N Sunaga, K Kaira, H Imai, K Shimizu, T Nakano… - Oncogene, 2013 - nature.com
KRAS mutations are one of the most common driver mutations in non-small-cell lung cancer
(NSCLC) and finding druggable target molecules to inhibit oncogenic KRAS signaling is a …
(NSCLC) and finding druggable target molecules to inhibit oncogenic KRAS signaling is a …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Targeting the EGFR signaling pathway in cancer therapy
P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor
G Auf, A Jabouille, M Delugin, S Guérit, R Pineau… - BMc cancer, 2013 - Springer
Background Epidermal growth factor (EGF) receptors contribute to the development of
malignant glioma. Here we considered the possible implication of the EGFR ligand …
malignant glioma. Here we considered the possible implication of the EGFR ligand …
Epidermal growth factor signaling in transformed cells
S Lindsey, SA Langhans - International review of cell and molecular …, 2015 - Elsevier
Members of the epidermal growth factor receptor (EGFR/ErbB) family play a critical role in
normal cell growth and development. However, many ErbB family members, especially …
normal cell growth and development. However, many ErbB family members, especially …
[HTML][HTML] The nuclear epidermal growth factor receptor signaling network and its role in cancer
TM Brand, M Iida, C Li, DL Wheeler - Discovery medicine, 2011 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo
Despite a well-established role for the epidermal growth factor receptor (EGFR) in
tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We …
tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We …
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis
MV Grandal, IH Madshus - Journal of cellular and molecular …, 2008 - Wiley Online Library
• Introduction• Endocytosis of EGFR‐Kinase activity‐Clathrin‐coated pits‐Ubiquitination‐
Effects of EGFR‐ErbB2 heterodimerization on EGFR internalization• Cellular and molecular …
Effects of EGFR‐ErbB2 heterodimerization on EGFR internalization• Cellular and molecular …
Epidermal growth factor receptor in relation to tumor development: EGFR‐targeted anticancer therapy
I Okamoto - The FEBS journal, 2010 - Wiley Online Library
The discovery that signaling by the epidermal growth factor receptor (EGFR) plays a key role
in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different …
in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different …