Contribution of statins towards periodontal treatment: a review

C Petit, F Batool, IM Bugueno, P Schwinté… - Mediators of …, 2019 - Wiley Online Library
The pleiotropic effects of statins have been evaluated to assess their potential benefit in the
treatment of various inflammatory and immune‐mediated diseases including periodontitis …

Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta‐analysis of preclinical in vivo trials

K Bertl, I Steiner, N Pandis, K Buhlin… - Journal of …, 2018 - Wiley Online Library
The cholesterol‐lowering drugs, statins, possess anti‐inflammatory, antimicrobial and pro‐
osteogenic properties, and thus have been tested as an adjunct to periodontal treatment …

Pleiotropic effects of statins on the treatment of chronic periodontitis–a systematic review

IMG Estanislau, IRC Terceiro… - British journal of …, 2015 - Wiley Online Library
Aim Statins are inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase and are an
important group of hypolipidaemic drugs, widely used in the treatment of …

Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a meta‐analysis

Z Akram, F Vohra, F Javed - Journal of Investigative and …, 2018 - Wiley Online Library
The action of statins in stimulating bone formation and having other pleiotropic effects, such
as anti‐inflammatory and immunomodulatory effects, has justified their use as an adjunct to …

The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression

FWMG Muniz, K Taminski, J Cavagni… - Clinical oral …, 2018 - Springer
Objective This study aimed to systematically review clinical trials about the effect of statins as
adjunct to mechanical periodontal therapy, on probing pocket depth, clinical attachment …

The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy—A systematic review and meta-analysis

K Bertl, A Parllaku, N Pandis, K Buhlin, B Klinge… - Journal of dentistry, 2017 - Elsevier
Objectives To evaluate the effect of local and/or systemic statin use as an adjunct to non-
surgical and/or surgical periodontal therapy. Data Literature search according to PRISMA …

The effect of locally delivered statins on treating periodontal intrabony defects: a systematic review and meta‐analysis

K Sinjab, N Zimmo, GH Lin, MP Chung… - Journal of …, 2017 - Wiley Online Library
Background: Use of statins on adult patients with chronic periodontitis shows a positive
effect on their periodontal status. However, effect of locally delivered statins on periodontal …

The effects of statins on dental and oral health: a review of preclinical and clinical studies

S Tahamtan, F Shirban, M Bagherniya… - Journal of translational …, 2020 - Springer
The statin family of drugs are safe and effective therapeutic agents for the treatment of
arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in …

Periodontal and peri-implant diseases and systemically administered statins: A systematic review

F Di Spirito, L Schiavo, V Pilone, A Lanza, L Sbordone… - Dentistry Journal, 2021 - mdpi.com
Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn,
acts as a contributory factor in periodontitis development. Periodontitis has been associated …

Simvastatin inhibits lipopolysaccharide‐induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease

J Jin, X Zhang, Z Lu, Y Li… - Journal of …, 2014 - Wiley Online Library
Background and Objective Statins are inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A
reductase and have anti‐inflammatory effects independent of cholesterol lowering. Recent …