Background Dilated cardiomyopathy is characterized by an imbalance between left
ventricular performance and myocardial energy consumption. Experimental models suggest …

Aims Oxidative stress, ie imbalance between reactive oxygen species (ROS) and antioxidant
defences, contributes to the progression of chronic heart failure (CHF). Acute inhibition of …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

Objectives: This study tested the hypothesis that acute administration of the xanthine
oxidase (XO) inhibitor allopurinol improves cardiac high-energy phosphate concentrations …

Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

Background—Accumulating evidence suggests a critical role for increased reactive oxygen
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …

Objectives: This study sought to ascertain whether high-dose allopurinol causes regression
of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM). Background …

Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …