Recombinant mucin biotechnology and engineering

S Park, JCH Kuo, HL Reesink, MJ Paszek - Advanced drug delivery reviews, 2023 - Elsevier
Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

Design and Synthesis of Mucin‐Inspired Glycopolymers

CS Kwan, AR Cerullo, AB Braunschweig - ChemPlusChem, 2020 - Wiley Online Library
Mucins are bottlebrush biopolymers that are glycoproteins on the surfaces of cells and as
hydrogels secreted inside and outside the body. Mucin function in biology includes cell‐cell …

Advances in mucin mimic synthesis and applications in surface science

LA Navarro, DL French, S Zauscher - Current Opinion in Colloid & Interface …, 2018 - Elsevier
Highlights•Mucins are a class of heavily glycosylated glycoproteins.•Mucin use is inhibited
by batch heterogeneity, motivating synthesis of mucin mimics.•Mucin mimics can be …

Preparation and applications of artificial mucins in biomedicine

RE Detwiler, JR Kramer - Current Opinion in Solid State and Materials …, 2022 - Elsevier
Mucus is an essential barrier material that separates organisms from the outside world. This
slippery material regulates the transport of nutrients, drugs, gases, and pathogens toward …

Mirror Image Mucins and Thio Mucins with Tunable Biodegradation

VR Kohout, CL Wardzala… - Journal of the American …, 2023 - ACS Publications
Mucin glycoproteins are the major component of mucus and are integral to the cellular
glycocalyx. Mucins play diverse roles in health and disease, are an important element in …

Structural alterations of mucins are associated with losses in functionality

M Marczynski, K Jiang, M Blakeley… - …, 2021 - ACS Publications
Commercial mucin glycoproteins are routinely used as a model to investigate the broad
range of important functions mucins fulfill in our bodies, including lubrication, protection …

Synthesis and biomedical applications of mucin mimic materials

VR Kohout, CL Wardzala, JR Kramer - Advanced drug delivery reviews, 2022 - Elsevier
Mucin glycoproteins are the major component of mucus and coat epithelial cell surfaces
forming the glycocalyx. The glycocalyx and mucus are involved in the transport of nutrients …

Advances in mucin biopolymer research: Purification, characterization, and applications

M Marczynski, B Winkeljann… - … for Biomedical and …, 2021 - Wiley Online Library
This book chapter highlights mucins as macromolecular components for liquids, coatings, or
hydrogels that seek an application in biomedical engineering. We summarize current …

Chemically tunable mucin chimeras assembled on living cells

JR Kramer, B Onoa, C Bustamante… - Proceedings of the …, 2015 - National Acad Sciences
Mucins are a family of secreted and transmembrane glycoproteins characterized by a
massive domain of dense O-glycosylation on serine and threonine residues. Mucins are …

[HTML][HTML] Display of the human mucinome with defined O-glycans by gene engineered cells

R Nason, C Büll, A Konstantinidi, L Sun, Z Ye… - Nature …, 2021 - nature.com
Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …