Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular
insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional …

Skeletal muscle is a major mass peripheral tissue that accounts for∼ 40% of the total body
mass and a major player in energy balance. It accounts for> 30% of energy expenditure, is …

Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which
leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest …

Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that bind DNA
and translate physiological signals into gene regulation. The therapeutic utility of NRs is …

Exercise has a profound effect on cardiovascular disease, particularly through vascular
remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular …

About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the
prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia …

Skeletal muscle ischemia is a major consequence of peripheral arterial disease (PAD) or
critical limb ischemia (CLI). While therapeutic options for resolving muscle ischemia in …

Skeletal muscle comprises the largest organ in the human body and is the major site for
energy expenditure. It exhibits remarkable plasticity in response to physiological stimuli such …

Skeletal muscle is not only one of the largest, but also one of the most dynamic organs. For
example, plasticity elicited by endurance or resistance exercise entails complex …

Background Peripheral arterial disease and critical limb ischemia are cardiovascular
complications associated with vascular insufficiency, oxidative metabolic dysfunction, and …