In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-
gene-based association studies have been supplanted by exome sequencing, genome …

With the advent of genome-wide association studies (GWAS) and next-generation
sequencing, more than 20 risk loci that affect Alzheimer's disease have been identified …

Background Alzheimer's disease is a debilitating and highly heritable neurological
condition. As such, genetic studies have sought to understand the genetic architecture of …

Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …

Background The causes of phenotypic heterogeneity in familial Alzheimer's disease with
autosomal dominant inheritance are not well understood. We aimed to characterise clinical …

Over the past two decades, the landscape of dementia research has changed drastically
due to advances in knowledge at the molecular, cellular, animal, and human levels …

An explosion of new techniques to explore DNA and protein biology during the last 2
decades has illuminated one of the most enigmatic and intractable subjects in bio-medicine …

Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …

The cause of Alzheimer's disease (AD) is unknown. This gap in knowledge has created a
stumbling block in the search for a genuinely effective treatment or cure for this dementia …

Alzheimer's disease and other idiopathic dementias are associated with epigenetic
transformations. These transformations connect the environment and genes to …