Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

Mesenchymal stem cells (MSCs)-derived exosomes are being increasingly focused as the
new biological pro-regenerative therapeutic agents for various types of tissue injury. Here …

Background: Recent studies have shown the great value of cell therapy over the past few
decades. Mesenchymal stem cells (MSCs) have been reported to treat various degenerative …

Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints.
These disorders are very painful and severely limit patients' mobility and are more common …

Age-associated musculoskeletal disorders (MSDs) have been historically overlooked by
mainstream biopharmaceutical researchers. However, it has now been recognized that stem …

Despite traditionally treating autologous and allogeneic transplantation and emerging tissue
engineering (TE)-based therapies, which have commonly performed in clinic for skeletal …

Mesenchymal stem cell-based therapy has become an effective therapeutic approach for
bone regeneration. However, there are still limitations in successful clinical translation …

Within the field of regenerative medicine, many have sought to use stem cells as a promising
way to heal human tissue; however, in the past few years, exosomes (packaged vesicles …

Tendon injuries are common musculoskeletal system disorders in clinical, but the
regeneration ability of tendon is limited. Tendon stem cells (TSCs) have shown promising …

Abstract Background Rotator cuff tears (RCTs) often require reconstructive surgery. Tendon-
bone healing is critical for the outcome of rotator cuff reconstruction, but the process of …