Ebola virus causes severe hemorrhagic fever with high mortality rates in humans and
nonhuman primates. Vascular instability and dysregulation are disease-decisive symptoms …

Here we defined the main viral determinant of Ebola virus pathogenicity; synthesis of the
virion glycoprotein (GP) of Ebola virus Zaire induced cytotoxic effects in human endothelial …

During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed
from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE …

Filoviruses, including Ebola virus, are cytotoxic. To investigate the role of the Ebola virus
glycoprotein (GP) in this cytopathic effect, we transiently expressed the GP in human kidney …

Ebola virus, a member of the family Filoviridae, causes one of the most severe forms of viral
hemorrhagic fever. In the terminal stages of disease, symptoms progress to hypotension …

The Ebola virus envelope glycoprotein (GP) derived from the pathogenic Zaire subtype
mediates cell rounding and detachment from the extracellular matrix in 293T cells. In this …

Transient expression of Ebola virus (EBOV) glycoprotein GP causes downregulation of
surface proteins, cell rounding and detachment, a phenomenon believed to play a central …

Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV
primarily targets mononuclear phagocytes, which are activated upon infection and secrete …

In addition to the transmembrane protein, GP1, 2, the Ebola virus glycoprotein gene
encodes the soluble glycoproteins sGP and Δ‐peptide. Two more soluble proteins, GP1 and …

The high pathogenicity of the Ebola virus reflects multiple concurrent processes on infection.
Among other important determinants, Ebola fusogenic glycoprotein (GP) has been …