Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation
Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
A Multidimensional Approach to Modulating Ionizable Lipids for High‐Performing and Organ‐Selective mRNA Delivery
The development of lipid nanoparticles (LNPs) has enabled a successful clinical application
of mRNA vaccines. However, disclosure of design principles for the core component …
of mRNA vaccines. However, disclosure of design principles for the core component …
Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
Role of ionizable lipids in SARS-CoV-2 vaccines as revealed by molecular dynamics simulations: from membrane structure to interaction with mRNA fragments
M Paloncýová, P Čechová, M Šrejber… - The journal of …, 2021 - ACS Publications
Recent advances in RNA-based medicine have provided new opportunities for the global
current challenge, ie, the COVID-19 pandemic. Novel vaccines are based on a messenger …
current challenge, ie, the COVID-19 pandemic. Novel vaccines are based on a messenger …
[HTML][HTML] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA …
Y Sato, N Okabe, Y Note, K Hashiba, M Maeki… - Acta biomaterialia, 2020 - Elsevier
Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue
penetration and efficient drug delivery, their poor stability and intracellular trafficking …
penetration and efficient drug delivery, their poor stability and intracellular trafficking …
Deconvoluting lipid nanoparticle structure for messenger RNA delivery
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
Developing biodegradable lipid nanoparticles for intracellular mRNA delivery and genome editing
Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …
Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid …
Despite the worldwide success of mRNA-LNP Covid-19 vaccines, the nanoscale structures
of these formulations are still poorly understood. To fill this gap, we used a combination of …
of these formulations are still poorly understood. To fill this gap, we used a combination of …
[HTML][HTML] mRNA lipid nanoparticle phase transition
MFW Trollmann, RA Böckmann - Biophysical Journal, 2022 - cell.com
Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid
nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics …
nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics …
Ionizable amino lipids distribution and effects on DSPC/cholesterol membranes: implications for lipid nanoparticle structure
S Dehghani-Ghahnaviyeh, M Smith, Y Xia… - The Journal of …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) containing ionizable aminolipids are among the leading
platforms for the successful delivery of nucleic-acid-based therapeutics, including …
platforms for the successful delivery of nucleic-acid-based therapeutics, including …