Comparative studies of different preservation methods and relative freeze-drying formulations for extracellular vesicle pharmaceutical applications

F Susa, T Limongi, F Borgione, S Peiretti… - ACS Biomaterials …, 2023 - ACS Publications
Extracellular vesicles (EVs) have been studied for years for their role as effectors and
mediators of cell-to-cell communication and their potential application to develop new and …

Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation

F Yuan, YM Li, Z Wang - Drug Delivery, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are nanovesicles released by various cell types. EVs are known
for cell-to-cell communications and have potent biological activities. Despite great progress …

Preservation and storage stability of extracellular vesicles for therapeutic applications

A Jeyaram, SM Jay - The AAPS journal, 2018 - Springer
Abstract Recently, extracellular vesicles (EVs)—including exosomes, microvesicles, and
others—have attracted interest as cell-derived biotherapeutics and drug delivery vehicles for …

Efficient extracellular vesicles freeze-dry method for direct formulations preparation and use

M Guarro, F Suñer, M Lecina, S Borrós… - Colloids and Surfaces B …, 2022 - Elsevier
Despite the great knowledge achieved in the field of extracellular vesicles (EVs), the short
lifetime of EVs liquid formulation still hampers the transfer of EVs technology to clinical …

Cell derived extracellular vesicles: from isolation to functionalization and biomedical applications

L Zhu, N Xu, ZL Zhang, TC Zhang - Biomaterials science, 2019 - pubs.rsc.org
Extracellular vesicles (EVs) are shed from most mammalian cells by different processes. EVs
possess several distinct advantages, including excellent biocompatibility, good bio-stability …

Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions

JY Wu, YJ Li, XB Hu, S Huang, DX Xiang - Drug Delivery, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are nanovesicles involved in multiple biological functions. Small
EVs (sEVs) are emerging as therapeutics and drug delivery systems for their contents …

Identification of storage conditions stabilizing extracellular vesicles preparations

A Görgens, G Corso, DW Hagey… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …

Generation, purification and engineering of extracellular vesicles and their biomedical applications

J Gao, X Dong, Z Wang - Methods, 2020 - Elsevier
Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be
excellent therapeutics and drug carriers. Although EVs are promising, the process to …

[HTML][HTML] Unveiling the Complex World of Extracellular Vesicles: Novel Characterization Techniques and Manufacturing Considerations

JJ Lai, JJ Hill, CY Huang, GC Lee, KW Mai… - Chonnam Medical …, 2024 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) function as potent mediators of intercellular communication for
many in vivo processes, contributing to both health and disease related conditions. Given …

To protect and to preserve: novel preservation strategies for extracellular vesicles

GD Kusuma, M Barabadi, JL Tan… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by
stem cells exert similar therapeutic effects and these have been proposed as an alternative …